"Sideways" turns inside out in "Transamerica." Laugh-out-loud funny, tartly off-color and ultimately touching, this road movie involving the cross-country adventures of a persnickety transsexual, and the runaway street hustler son whose existence is news to her, reps a triumphantly genre-bending big-screen bow for writer-director Duncan Tucker. An adventurous U.S. distrib willing to put marketing muscle behind an outspoken comedy, one that feels like vintage John Waters scripted by Alexander Payne and Jim Taylor, could reap controversy of the former's works and approach kudos-driven B.O. of the latters.' Internationally, it should travel well beyond niche fests to develop crossover appeal in theatrical and homevid.

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